Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells throu...
Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming
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Author / Creator
Wu, Hao , Zhao, Xiufeng , Hochrein, Sophia M. , Eckstein, Miriam , Gubert, Gabriela F. , Knöpper, Konrad , Mansilla, Ana Maria , Öner, Arman , Doucet-Ladevèze, Remi , Schmitz, Werner , Ghesquière, Bart , Theurich, Sebastian , Dudek, Jan , Gasteiger, Georg , Zernecke, Alma , Kobold, Sebastian , Kastenmüller, Wolfgang and Vaeth, Martin
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precursor population (Tpex), but the metabolic principles governing Tpex maintenance and the regulatory circuits t...
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Full title
Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming
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TN_cdi_doaj_primary_oai_doaj_org_article_8569ec630ff141898b05f8e21eb43d82
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8569ec630ff141898b05f8e21eb43d82
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42634-3
