Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomizati...
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
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Author / Creator
Brumpton, Ben , Sanderson, Eleanor , Heilbron, Karl , Hartwig, Fernando Pires , Harrison, Sean , Vie, Gunnhild Åberge , Cho, Yoonsu , Howe, Laura D. , Hughes, Amanda , Boomsma, Dorret I. , Havdahl, Alexandra , Hopper, John , Neale, Michael , Nivard, Michel G. , Pedersen, Nancy L. , Reynolds, Chandra A. , Tucker-Drob, Elliot M. , Grotzinger, Andrew , Howe, Laurence , Morris, Tim , Li, Shuai , Auton, Adam , Windmeijer, Frank , Chen, Wei-Min , Bjørngaard, Johan Håkon , Hveem, Kristian , Willer, Cristen , Evans, David M. , Kaprio, Jaakko , Davey Smith, George , Åsvold, Bjørn Olav , Hemani, Gibran , Davies, Neil M. , The Within-family Consortium , The 23andMe Research Team , 23andMe Research Team and Within-family Consortium
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biases. We illustrate empirically how familial effects...
Alternative Titles
Full title
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Authors, Artists and Contributors
Author / Creator
Sanderson, Eleanor
Heilbron, Karl
Hartwig, Fernando Pires
Harrison, Sean
Vie, Gunnhild Åberge
Cho, Yoonsu
Howe, Laura D.
Hughes, Amanda
Boomsma, Dorret I.
Havdahl, Alexandra
Hopper, John
Neale, Michael
Nivard, Michel G.
Pedersen, Nancy L.
Reynolds, Chandra A.
Tucker-Drob, Elliot M.
Grotzinger, Andrew
Howe, Laurence
Morris, Tim
Li, Shuai
Auton, Adam
Windmeijer, Frank
Chen, Wei-Min
Bjørngaard, Johan Håkon
Hveem, Kristian
Willer, Cristen
Evans, David M.
Kaprio, Jaakko
Davey Smith, George
Åsvold, Bjørn Olav
Hemani, Gibran
Davies, Neil M.
The Within-family Consortium
The 23andMe Research Team
23andMe Research Team
Within-family Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_85accda5604c471488ab1aecb46cd352
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_85accda5604c471488ab1aecb46cd352
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17117-4
