HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
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Author / Creator
Boczek, Edgar E , Fürsch, Julius , Niedermeier, Marie Laura , Jawerth, Louise , Jahnel, Marcus , Ruer-Gruß, Martine , Kammer, Kai-Michael , Heid, Peter , Mediani, Laura , Wang, Jie , Yan, Xiao , Pozniakovski, Andrej , Poser, Ina , Mateju, Daniel , Hubatsch, Lars , Carra, Serena , Alberti, Simon , Hyman, Anthony A and Stengel, Florian
Publisher
Cambridge: eLife Sciences Publications Ltd
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English
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Publisher
Cambridge: eLife Sciences Publications Ltd
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Contents
Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor protein interactions and dynamics inside condensates fo...
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Full title
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
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TN_cdi_doaj_primary_oai_doaj_org_article_85bf8344d0894177804ff718a7d76096
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_85bf8344d0894177804ff718a7d76096
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.69377
