Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore
Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Loss-of-function mutations of the CFTR gene cause the life-shortening genetic disease cystic fibrosis (CF), whereas overactivity of CFTR may lead to secretory diarrhea and polycystic kidney disease. While effective drugs targeting the CFTR protein have been developed for the treatment of CF, little progress has been made for diseases caused by hype...
Alternative Titles
Full title
Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore
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TN_cdi_doaj_primary_oai_doaj_org_article_86b783d0ca63434bb3730316e05145d3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_86b783d0ca63434bb3730316e05145d3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50641-1
