A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombin...
A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency
About this item
Full title
Author / Creator
Kohsaka, Shinji , Yagishita, Shigehiro , Shirai, Yukina , Matsuno, Yusuke , Ueno, Toshihide , Kojima, Shinya , Ikeuchi, Hiroshi , Ikegami, Masachika , Kitada, Rina , Yoshioka, Ken-ichi , Toshimitsu, Kohta , Tabata, Kimiyo , Yokoi, Akira , Doi, Toshihiko , Yamamoto, Noboru , Owa, Takashi , Hamada, Akinobu and Mano, Hiroyuki
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
E7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA splicing by degrading the splicing factor RBM39 via ternary complex formation with the E3 ligase adaptor DCAF15. To identify biomarkers of the antitumor efficacy of E7820, we treated patient-derived xenograft (PDX) mouse models established from 42 patients with solid tumo...
Alternative Titles
Full title
A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_86ebc4f788534403a85a1a26be337bd6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_86ebc4f788534403a85a1a26be337bd6
Other Identifiers
ISSN
2397-768X
E-ISSN
2397-768X
DOI
10.1038/s41698-024-00610-0
