Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway
Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway
About this item
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Author / Creator
Zhou, Lu , Zhang, Yi-Fei , Yang, Fu-Hua , Mao, Han-Qing , Chen, Zhi and Zhang, Lu
Publisher
England: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central
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Scope and Contents
Contents
Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway activation in infectious diseases. Odontoblasts are the first cells challenged by cariogenic bacteria and involved in maint...
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Full title
Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_871d249c1c5947fa96743410d958ebd8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_871d249c1c5947fa96743410d958ebd8
Other Identifiers
ISSN
1478-811X
E-ISSN
1478-811X
DOI
10.1186/s12964-021-00738-7
