E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis
E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis
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Author / Creator
Shi, Yuhua , Yang, Yang , Xu, Weilv , Shi, Dongyun , Xu, Wei , Fu, Xinyu , Lv, Qian , Xia, Jie and Shi, Fushan
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Gasdermin D (GSDMD) participates in the activation of inflammasomes and pyroptosis. Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how ubiquitination regulates Gasdermin D activity is not well understood. In this study, we show that pyroptosis triggered by Gasdermin D is regulated through ubiquitination. Specifically,...
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Full title
E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_87609be351564c209976c9f6f17dd5e7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_87609be351564c209976c9f6f17dd5e7
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-04553-x
