Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibit...
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition
About this item
Full title
Author / Creator
Paul, Sayantanee , Hagenbeek, Thijs J. , Tremblay, Julien , Kameswaran, Vasumathi , Ong, Christy , Liu, Chad , Guarnaccia, Alissa D. , Mondo, James A. , Hsu, Peter L. , Kljavin, Noelyn M. , Czech, Bartosz , Smola, Janina , Nguyen, Dieu An H. , Lacap, Jennifer A. , Pham, Trang H. , Liang, Yuxin , Blake, Robert A. , Gerosa, Luca , Grimmer, Matthew , Xie, Shiqi , Daniel, Bence , Yao, Xiaosai and Dey, Anwesha
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
TEAD (transcriptional enhanced associate domain) transcription factors (TEAD1-4) serve as the primary effectors of the Hippo signaling pathway in various cancers. Targeted therapy leads to the emergence of resistance and the underlying mechanism of resistance to TEAD inhibition in cancers is less characterized. We uncover that upregulation of the A...
Alternative Titles
Full title
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition
Authors, Artists and Contributors
Author / Creator
Hagenbeek, Thijs J.
Tremblay, Julien
Kameswaran, Vasumathi
Ong, Christy
Liu, Chad
Guarnaccia, Alissa D.
Mondo, James A.
Hsu, Peter L.
Kljavin, Noelyn M.
Czech, Bartosz
Smola, Janina
Nguyen, Dieu An H.
Lacap, Jennifer A.
Pham, Trang H.
Liang, Yuxin
Blake, Robert A.
Gerosa, Luca
Grimmer, Matthew
Xie, Shiqi
Daniel, Bence
Yao, Xiaosai
Dey, Anwesha
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_87da8a885e2f47428e42f07db0be928c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_87da8a885e2f47428e42f07db0be928c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-56634-y
