Divergent folding-mediated epistasis among unstable membrane protein variants
Divergent folding-mediated epistasis among unstable membrane protein variants
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evolutionary GnRHR modifications appear to have coincided with adaptive changes in cotranslational fold...
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Full title
Divergent folding-mediated epistasis among unstable membrane protein variants
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TN_cdi_doaj_primary_oai_doaj_org_article_87e6dc4267994ade8aebd09e14ada9b5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_87e6dc4267994ade8aebd09e14ada9b5
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.92406
