The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells fro...
The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The mitochondrial protein IF1 binds to the catalytic domain of the ATP synthase and inhibits ATP hydrolysis in ischemic tissues. Moreover, IF1 is overexpressed in many tumors and has been shown to act as a pro-oncogenic protein, although its mechanism of action is still debated. Here, we show that
ATP5IF1
gene disruption in HeLa cells decreas...
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The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_88067e01f93247babee88803fbde9796
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_88067e01f93247babee88803fbde9796
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-023-05572-y
