An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic pept...
An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Solvent shielding of the amide hydrogen bond donor (NH groups) through chemical modification or conformational control has been successfully utilized to impart membrane permeability to macrocyclic peptides. We demonstrate that passive membrane permeability can also be conferred by masking the amide hydrogen bond acceptor (>C = O) through a thioamid...
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Full title
An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides
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TN_cdi_doaj_primary_oai_doaj_org_article_886b2cd70a2e469783d0743ad0669cb4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_886b2cd70a2e469783d0743ad0669cb4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41748-y
