Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Nov...
Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Novel Ligands Targeting α4β2 and α7 Nicotinic Acetylcholine Receptors
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Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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The neuronal nicotinic acetylcholine receptors (nAChRs) belong to the ligand-gated ion channel (GLIC) group, presenting a crucial role in several biological processes and neuronal disorders. The α4β2 and α7 nAChRs are the most abundant in the central nervous system (CNS), being involved in challenging diseases such as epilepsy, Alzheimer’s disease,...
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Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Novel Ligands Targeting α4β2 and α7 Nicotinic Acetylcholine Receptors
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TN_cdi_doaj_primary_oai_doaj_org_article_889d6fbd2ecd446783a0284e3cf5799b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_889d6fbd2ecd446783a0284e3cf5799b
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27238236
