BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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BubR1 is a key component of the spindle assembly checkpoint (SAC). Mutations that reduce BubR1 abundance cause aneuploidization and tumorigenesis in humans and mice, whereas BubR1 overexpression protects against these. However, how supranormal BubR1 expression exerts these beneficial physiological impacts is poorly understood. Here, we used Bub1b m...
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BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_88af7186e82648198f1f19cdb2ccc619
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_88af7186e82648198f1f19cdb2ccc619
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.16620
