Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic...
Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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O
-mannosylated α-dystroglycan (α-DG) serves as receptors for cell–cell and cell–extracellular matrix adhesion and signaling. Hypoglycosylation of α-DG is involved in cancer progression and underlies dystroglycanopathy with aberrant neuronal development. Here we report that ribitol, a pentose alcohol with previously unknown function in mammalian...
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Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice
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TN_cdi_doaj_primary_oai_doaj_org_article_88d48ec703f1413292d3648e7e85ca53
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_88d48ec703f1413292d3648e7e85ca53
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05990-z
