Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mu...
Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Inherited germline mutations in the breast cancer gene 1 (BRCA1) or BRCA2 genes (herein BRCA1/2) greatly increase the risk of breast and ovarian cancer, presumably by elevating somatic mutational errors as a consequence of deficient DNA repair. However, this has never been directly demonstrated by a comprehensive analysis of the somatic mutational...
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Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers
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TN_cdi_doaj_primary_oai_doaj_org_article_88f073b576eb4d2d946165cf1fe3a4e1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_88f073b576eb4d2d946165cf1fe3a4e1
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI148113
