Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation t...
Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that requires CD28 signaling. Therefore, strategies that restrict the effects of costimulation blockade to effector...
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Full title
Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity
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TN_cdi_doaj_primary_oai_doaj_org_article_88fdb72320aa489eb09cc8536ed4b458
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_88fdb72320aa489eb09cc8536ed4b458
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34477-1
