Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkins...
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson's disease (PD). Recently, more than fifty other lysosomal storage disorder gene variants have been identified in PD, implicating lysosomal dysfunction more broadly as a key risk fac...
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Full title
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease
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TN_cdi_doaj_primary_oai_doaj_org_article_8a3bdc7450e34016b365323d7a34ab17
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8a3bdc7450e34016b365323d7a34ab17
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-019-0339-z
