β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal...
β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis
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Chen, Shuangqin , Li, Jiemei , Liang, Ye , Zhang, Meijia , Qiu, Ziqi , Liu, Sirui , Wang, HaoRan , Zhu, Ye , Song, Shicong , Hou, Xiaotao , Liu, Canzhen , Wu, Qinyu , Zhu, Mingsheng , Shen, Weiwei , Miao, Jinhua , Hou, Fan Fan , Liu, Youhua , Wang, Cheng and Zhou, Lili
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Liver kinase B1 (LKB1) is a serine/threonine kinase controlling cell homeostasis. Among post-translational modification, Sumoylation is vital for LKB1 activating adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK), the key regulator in energy metabolism. Of note, AMPK-regulated fatty acid metabolism is highly involved in maintaining no...
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β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis
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TN_cdi_doaj_primary_oai_doaj_org_article_8a534c718c894bdca2787573982d4682
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8a534c718c894bdca2787573982d4682
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-07154-y
