Mode of action of teixobactins in cellular membranes
Mode of action of teixobactins in cellular membranes
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Author / Creator
Shukla, Rhythm , Medeiros-Silva, João , Parmar, Anish , Vermeulen, Bram J. A. , Das, Sanjit , Paioni, Alessandra Lucini , Jekhmane, Shehrazade , Lorent, Joseph , Bonvin, Alexandre M. J. J. , Baldus, Marc , Lelli, Moreno , Veldhuizen, Edwin J. A. , Breukink, Eefjan , Singh, Ishwar and Weingarth, Markus
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The difficult synthesis and unfavourable solubility of teixobactin require modifications, yet insufficient knowledge on its binding mode impedes the hunt for superior analogues. Thus far, teixobactins are assumed to kill bacteria by binding to cognate cell w...
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Full title
Mode of action of teixobactins in cellular membranes
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8a53feac384048deba131cc874db54f3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8a53feac384048deba131cc874db54f3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16600-2
