A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and pr...
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity
About this item
Full title
Author / Creator
Ghoshal, Anirban , Tse, Edwin G. , Hossain, Mohammad Anwar , Asressu, Kesatebrhan Haile , Merten, Eric M. , Sears, John D. , Howell, Stefanie , Perveen, Sumera , Burdick, Jane , Morales, Noah L. , Martinez, Sabian A. , Law, Isabella , Davenport, Bennett J. , Morrison, Thomas E. , Streblow, Zachary J. , Streblow, Daniel N. , Mordant, Angie L. , Webb, Thomas S. , Cabrera, Aurora , Herring, Laura E. , Arrowsmith, Cheryl H. , Pearce, Kenneth H. , Moorman, Nathaniel J. , Heise, Mark T. , Couñago, Rafael M. , Brown, Peter J. and Willson, Timothy M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Chikungunya
is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (
3
) was identified as a potent inhibitor of the nsP2 cysteine protease (nsP2pro) that reduced viral titer against infectious isolates of
Chikungunya
and other alphavi...
Alternative Titles
Full title
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity
Authors, Artists and Contributors
Author / Creator
Tse, Edwin G.
Hossain, Mohammad Anwar
Asressu, Kesatebrhan Haile
Merten, Eric M.
Sears, John D.
Howell, Stefanie
Perveen, Sumera
Burdick, Jane
Morales, Noah L.
Martinez, Sabian A.
Law, Isabella
Davenport, Bennett J.
Morrison, Thomas E.
Streblow, Zachary J.
Streblow, Daniel N.
Mordant, Angie L.
Webb, Thomas S.
Cabrera, Aurora
Herring, Laura E.
Arrowsmith, Cheryl H.
Pearce, Kenneth H.
Moorman, Nathaniel J.
Heise, Mark T.
Couñago, Rafael M.
Brown, Peter J.
Willson, Timothy M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8aca8b6ee16a4bd28a2ac2f20004c49b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8aca8b6ee16a4bd28a2ac2f20004c49b
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-025-91673-x
