Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Park...
Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson’s disease model
About this item
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Author / Creator
Xu, Peibo , He, Hui , Gao, Qinqin , Zhou, Yingying , Wu, Ziyan , Zhang, Xiao , Sun, Linyu , Hu, Gang , Guan, Qian , You, Zhiwen , Zhang, Xinyue , Zheng, Wenping , Xiong, Man and Chen, Yuejun
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
Ann Arbor: American Society for Clinical Investigation
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Scope and Contents
Contents
Human pluripotent stem cell-based (hPSC-based) replacement therapy holds great promise for the treatment of Parkinson's disease (PD). However, the heterogeneity of hPSC-derived donor cells and the low yield of midbrain dopaminergic (mDA) neurons after transplantation hinder its broad clinical application. Here, we have characterized the single-cell...
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Full title
Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson’s disease model
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8ae27e7acfc54992aecd1c3c5b1f342d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8ae27e7acfc54992aecd1c3c5b1f342d
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI156768
