Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
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Author / Creator
Zhang, Liyuan , Dong, Yue , Zhang, Luxin , Wang, Minjun , Zhou, Ye , Jia, Kaiwei , Wang, Suyuan , Wang, Mu , Li, Yunhui , Luo, Shudan , Lu, Shan , Fan, Yiwen , Zhang, Dingji , Yang, Yingyun , Li, Nan , Yu, Yizhi , Cao, Xuetao and Hou, Jin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated. Immunoresponsive gene 1 (IRG1) and its enzymatic metabolite itaconate are known to suppress inflammation in myeloid cells, and its expression in liver...
Alternative Titles
Full title
Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8b0643ea588b4493b347879a6c25e75c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8b0643ea588b4493b347879a6c25e75c
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-023-06155-7
