PRL2 negatively regulates FcεRI mediated activation of mast cells
PRL2 negatively regulates FcεRI mediated activation of mast cells
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Author / Creator
Guo, Xin , Lei, Yunxuan , Xu, Yanhua , Du, Xinyue , Lin, Lin , Luo, Yanping , Xi, Yebin , Guo, Yinshi , Niu, Xiaoyin , Wang, Zhaojun and Chen, Guangjie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mast cells play a central role in allergic reactions, acting as key effector cells that initiate and amplify the inflammatory response. In this study, we demonstrate that phosphatase of regenerating liver 2 (PRL2) functions as a negative regulator of FcεRI-mediated mast cell activation. In PRL2-deficient myeloid cells, PRL2 conditional knockout mic...
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Full title
PRL2 negatively regulates FcεRI mediated activation of mast cells
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TN_cdi_doaj_primary_oai_doaj_org_article_8b936325a22f4bc09114a4e261244f27
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8b936325a22f4bc09114a4e261244f27
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-025-07649-2
