Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomer...
Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
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Author / Creator
Kim, So Yeon , Jeong, Jong-Min , Kim, Soo Jin , Seo, Wonhyo , Kim, Myung-Ho , Choi, Won-Mook , Yoo, Wonbeak , Lee, Jun-Hee , Shim, Young-Ri , Yi, Hyon-Seung , Lee, Young-Sun , Eun, Hyuk Soo , Lee, Byung Seok , Chun, Kwangsik , Kang, Suk-Jo , Kim, Sun Chang , Gao, Bin , Kunos, George , Kim, Ho Min and Jeong, Won-Il
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b
+
F4/80
low
hepatic infiltrating macrophag...
Alternative Titles
Full title
Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8bb1e950316b49bfbfc161b1e107780f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8bb1e950316b49bfbfc161b1e107780f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02325-2
