Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hem...
Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hematologic malignancy in mice
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Author / Creator
Yu, Chunjie , Sheng, Yue , Yu, Fang , Ni, Hongyu , Qiu, Alan , Huang, Yong and Qian, Zhijian
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Clonal hematopoiesis plays a critical role in the initiation and development of hematologic malignancies. In patients with del(5q) myelodysplastic syndrome (MDS), the transcription factor FOXM1 is frequently downregulated in CD34+ cells. In this study, we demonstrated that Foxm1 haploinsufficiency disturbed normal hematopoiesis and conferred a comp...
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Full title
Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hematologic malignancy in mice
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8bb657e9cc224d59a352f4a4605b6d40
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8bb657e9cc224d59a352f4a4605b6d40
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI163911
