Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracell...
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
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Author / Creator
Jiang, Lingyan , Wang, Peisheng , Song, Xiaorui , Zhang, Huan , Ma, Shuangshuang , Wang, Jingting , Li, Wanwu , Lv, Runxia , Liu, Xiaoqian , Ma, Shuai , Yan, Jiaqi , Zhou, Haiyan , Huang, Di , Cheng, Zhihui , Yang, Chen , Feng, Lu and Wang, Lei
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Salmonella
Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with
S
. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are mediated by bacterial protein SopE2, a...
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Full title
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
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TN_cdi_doaj_primary_oai_doaj_org_article_8c110fad8e2343f2846c5caea046f6e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c110fad8e2343f2846c5caea046f6e1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21186-4
