Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s di...
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease
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Author / Creator
Park, Jong-Sung , Kam, Tae-In , Lee, Saebom , Park, Hyejin , Oh, Yumin , Kwon, Seung-Hwan , Song, Jae-Jin , Kim, Donghoon , Kim, Hyunhee , Jhaldiyal, Aanishaa , Lee, Kang Choon , Park, Eun Ji , Pomper, Martin G. , Pletnikova, Olga , Troncoso, Juan C. , Ko, Han Seok , Dawson, Valina L. , Dawson, Ted M. and Lee, Seulki
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Alzheimer’s disease (AD) is the most common cause of age-related dementia. Increasing evidence suggests that neuroinflammation mediated by microglia and astrocytes contributes to disease progression and severity in AD and other neurodegenerative disorders. During AD progression, resident microglia undergo proinflammatory activation, resulting in an...
Alternative Titles
Full title
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_8c12a20bbf914cb084511984a12e33ad
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c12a20bbf914cb084511984a12e33ad
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01180-z
