Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
About this item
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Author / Creator
Ratnaparkhe, Manasi , Wong, John K. L. , Wei, Pei-Chi , Hlevnjak, Mario , Kolb, Thorsten , Simovic, Milena , Haag, Daniel , Paul, Yashna , Devens, Frauke , Northcott, Paul , Jones, David T. W. , Kool, Marcel , Jauch, Anna , Pastorczak, Agata , Mlynarski, Wojciech , Korshunov, Andrey , Kumar, Rajiv , Downing, Susanna M. , Pfister, Stefan M. , Zapatka, Marc , McKinnon, Peter J. , Alt, Frederick W. , Lichter, Peter and Ernst, Aurélie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (
n
= 16/26) in brain tumors developing in mice deficient for factors involved in homologous-recombination-repair or non-homologous-end-joining. Catastrophic event...
Alternative Titles
Full title
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Authors, Artists and Contributors
Author / Creator
Wong, John K. L.
Wei, Pei-Chi
Hlevnjak, Mario
Kolb, Thorsten
Simovic, Milena
Haag, Daniel
Paul, Yashna
Devens, Frauke
Northcott, Paul
Jones, David T. W.
Kool, Marcel
Jauch, Anna
Pastorczak, Agata
Mlynarski, Wojciech
Korshunov, Andrey
Kumar, Rajiv
Downing, Susanna M.
Pfister, Stefan M.
Zapatka, Marc
McKinnon, Peter J.
Alt, Frederick W.
Lichter, Peter
Ernst, Aurélie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8c14a72fa08b47349febd37357e6a636
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c14a72fa08b47349febd37357e6a636
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06925-4
