Lattice engineering enables definition of molecular features allowing for potent small-molecule inhi...
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
About this item
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Author / Creator
National Institutes of Health (NIH), Bethesda, MD (United States) , Lai, Yen-Ting , Wang, Tao , O’Dell, Sijy , Louder, Mark K. , Schön, Arne , Cheung, Crystal S. F. , Chuang, Gwo-Yu , Druz, Aliaksandr , Lin, Bob , McKee, Krisha , Peng, Dongjun , Yang, Yongping , Zhang, Baoshan , Herschhorn, Alon , Sodroski, Joseph , Bailer, Robert T. , Doria-Rose, Nicole A. , Mascola, John R. , Langley, David R. and Kwong, Peter D.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Diverse entry inhibitors targeting the gp120 subunit of the HIV-1 envelope (Env) trimer have been developed including BMS-626529, also called temsavir, a prodrug version of which is currently in phase III clinical trials. Here we report the characterization of a panel of small-molecule inhibitors including BMS-818251, which we show to be >10-fold m...
Alternative Titles
Full title
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
Authors, Artists and Contributors
Author / Creator
Lai, Yen-Ting
Wang, Tao
O’Dell, Sijy
Louder, Mark K.
Schön, Arne
Cheung, Crystal S. F.
Chuang, Gwo-Yu
Druz, Aliaksandr
Lin, Bob
McKee, Krisha
Peng, Dongjun
Yang, Yongping
Zhang, Baoshan
Herschhorn, Alon
Sodroski, Joseph
Bailer, Robert T.
Doria-Rose, Nicole A.
Mascola, John R.
Langley, David R.
Kwong, Peter D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8c1780f80cef41df909afde553e1a2ab
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c1780f80cef41df909afde553e1a2ab
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07851-1
