Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody dive...
Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Antibodies, essential components of adaptive immunity, derive their remarkable diversity primarily from V(D)J gene rearrangements, particularly within the heavy chain complementarity-determining region 3 (CDR-H3) where D genes play a major role. Traditionally, D genes were thought to recombine only in the forward direction, despite having identical...
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Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity
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TN_cdi_doaj_primary_oai_doaj_org_article_8c1e37d38f5d46848ed34deea10d0e72
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c1e37d38f5d46848ed34deea10d0e72
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-024-07441-6
