Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast...
Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER)-positive breast cancer. In this study, we aimed to determine acquired genomic changes in endocrine-resistant disease.
We performed DNA/RNA hybrid-capture sequencing on 12 locoregional recurrences after long-term estrogen deprivation and identified acquired genomic chan...
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Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences
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TN_cdi_doaj_primary_oai_doaj_org_article_8c263986a9324a718707574875504a29
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c263986a9324a718707574875504a29
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ISSN
1465-542X,1465-5411
E-ISSN
1465-542X
DOI
10.1186/s13058-020-01379-3
