Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature is exploited by cancer therapies to either increase RS to unbearable levels or inhibit checkpoint kinases involved in the DNA damage response. Thus far, treatments that combine these two strategies have shown pr...
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Full title
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
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TN_cdi_doaj_primary_oai_doaj_org_article_8c263bb60f8a421f9b29dbf5e254f232
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c263bb60f8a421f9b29dbf5e254f232
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.104718
