Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral...
Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape
About this item
Full title
Author / Creator
Golkaram, Mahdi , Kuo, Fengshen , Gupta, Sounak , Carlo, Maria I. , Salmans, Michael L. , Vijayaraghavan, Raakhee , Tang, Cerise , Makarov, Vlad , Rappold, Phillip , Blum, Kyle A. , Zhao, Chen , Mehio, Rami , Zhang, Shile , Godsey, Jim , Pawlowski, Traci , DiNatale, Renzo G. , Morris, Luc G. T. , Durack, Jeremy , Russo, Paul , Kotecha, Ritesh R. , Coleman, Jonathan , Chen, Ying-Bei , Reuter, Victor E. , Motzer, Robert J. , Voss, Martin H. , Liu, Li , Reznik, Ed , Chan, Timothy A. and Hakimi, A. Ari
Publisher
England: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central
Subjects
More information
Scope and Contents
Contents
Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we seek to elucidate how ITH and tumor evolution during immune checkpoint inhibitor (ICI) treatment can lead to therapy resistance.
Here, we completed a single-arm pilot stud...
Alternative Titles
Full title
Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape
Authors, Artists and Contributors
Author / Creator
Kuo, Fengshen
Gupta, Sounak
Carlo, Maria I.
Salmans, Michael L.
Vijayaraghavan, Raakhee
Tang, Cerise
Makarov, Vlad
Rappold, Phillip
Blum, Kyle A.
Zhao, Chen
Mehio, Rami
Zhang, Shile
Godsey, Jim
Pawlowski, Traci
DiNatale, Renzo G.
Morris, Luc G. T.
Durack, Jeremy
Russo, Paul
Kotecha, Ritesh R.
Coleman, Jonathan
Chen, Ying-Bei
Reuter, Victor E.
Motzer, Robert J.
Voss, Martin H.
Liu, Li
Reznik, Ed
Chan, Timothy A.
Hakimi, A. Ari
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8c4d235ff17b43c89e96ac2ab598a085
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c4d235ff17b43c89e96ac2ab598a085
Other Identifiers
ISSN
1756-994X
E-ISSN
1756-994X
DOI
10.1186/s13073-022-01146-3
