Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐ass...
Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Tumor‐associated macrophages (TAMs) promote tumor growth and metastasis by suppressing tumor immune surveillance. Herein, we provide evidence that the immunosuppressive phenotype of TAMs is controlled by long‐chain fatty acid metabolism, specifically unsaturated fatty acids, here exemplified by oleate. Consequently, en‐route enriched lipid droplets...
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Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
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TN_cdi_doaj_primary_oai_doaj_org_article_8c67af085da04323ba732ea32b84e9f4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c67af085da04323ba732ea32b84e9f4
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201910698
