Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplan...
Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery
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Author / Creator
Green, Michael M. B. , Chao, Nelson , Chhabra, Saurabh , Corbet, Kelly , Gasparetto, Cristina , Horwitz, Ari , Li, Zhiguo , Venkata, Jagadish Kummetha , Long, Gwynn , Mims, Alice , Rizzieri, David , Sarantopoulos, Stefanie , Stuart, Robert , Sung, Anthony D. , Sullivan, Keith M. , Costa, Luciano , Horwitz, Mitchell and Kang, Yubin
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic stem cell transplantation (HSCT) promotes hematopoiesis by inducing HSC proliferation.
We conducted a phase I/II trial of plerixafor...
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Full title
Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8c773201044c41c09ecb20b399fbcb3c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c773201044c41c09ecb20b399fbcb3c
Other Identifiers
ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-016-0301-2
