Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylo...
Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
About this item
Full title
Author / Creator
Monk, Ian R. , Shaikh, Nausad , Begg, Stephanie L. , Gajdiss, Mike , Sharkey, Liam K. R. , Lee, Jean Y. H. , Pidot, Sacha J. , Seemann, Torsten , Kuiper, Michael , Winnen, Brit , Hvorup, Rikki , Collins, Brett M. , Bierbaum, Gabriele , Udagedara, Saumya R. , Morey, Jacqueline R. , Pulyani, Neha , Howden, Benjamin P. , Maher, Megan J. , McDevitt, Christopher A. , King, Glenn F. and Stinear, Timothy P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
WalKR (YycFG) is the only essential two-component regulator in the human pathogen
Staphylococcus aureus
. WalKR regulates peptidoglycan synthesis, but this function alone does not explain its essentiality. Here, to further understand WalKR function, we investigate a suppressor mutant that arose when WalKR activity was impaired; a histidine to...
Alternative Titles
Full title
Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
Authors, Artists and Contributors
Author / Creator
Shaikh, Nausad
Begg, Stephanie L.
Gajdiss, Mike
Sharkey, Liam K. R.
Lee, Jean Y. H.
Pidot, Sacha J.
Seemann, Torsten
Kuiper, Michael
Winnen, Brit
Hvorup, Rikki
Collins, Brett M.
Bierbaum, Gabriele
Udagedara, Saumya R.
Morey, Jacqueline R.
Pulyani, Neha
Howden, Benjamin P.
Maher, Megan J.
McDevitt, Christopher A.
King, Glenn F.
Stinear, Timothy P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8c79c77e7e1c43c2b593eb5939e70c11
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8c79c77e7e1c43c2b593eb5939e70c11
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10932-4
