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Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malar...

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malar...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8cc8ea57ee8f4523a4e5535d94b2a3c5

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention

About this item

Full title

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2025-05, Vol.16 (1), p.4268-13, Article 4268

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Sulfadoxine-pyrimethamine (SP) is recommended for perennial malaria chemoprevention in young children in high burden areas across Africa. Mutations in the dihydropteroate synthase (
dhps
) gene (437 
G
/540
E
/581 
G
) associated with sulfadoxine resistance vary regionally, but their effect on SP protective efficacy is uncle...

Alternative Titles

Full title

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8cc8ea57ee8f4523a4e5535d94b2a3c5

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8cc8ea57ee8f4523a4e5535d94b2a3c5

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-025-58326-z

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