Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
AMP-activated protein kinase AMPK senses and regulates cellular energy state. AMPK activation by increasing AMP and ADP concentrations involves a conformational switch within the heterotrimeric complex. This is exploited here for the construction of a synthetic sensor of cellular energetics and allosteric AMPK activation, AMPfret. Based on engineer...
Alternative Titles
Full title
Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8d15448cd9064472a9bb9937a9aad01a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d15448cd9064472a9bb9937a9aad01a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08938-z
