Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening
Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening
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Yin, Kun , Zhao, Guihua , Xu, Chao , Qiu, Xiao , Wen, Biwei , Sun, Hui , Liu, Gongzhen , Liu, Ye , Zhao, Qingsong , Wei, Qingkuan , Huang, Bingcheng , Yan, Ge and Cao, Jianping
Publisher
England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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Rhoptry protein 18 (ROP18) is a key virulence factor of Toxoplasma gondii. The host's immune responses mediated by immune-related GTPases (IRGs) could be blocked by ROP18's kinase activity. ROP18 also interacts with various substrates, such as activating transcription factor 6 beta (ATF6β) and affects multiple physiological functions within host ce...
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Full title
Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening
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TN_cdi_doaj_primary_oai_doaj_org_article_8d1bd566d1ef45ee8751996b23711dac
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d1bd566d1ef45ee8751996b23711dac
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ISSN
1756-3305
E-ISSN
1756-3305
DOI
10.1186/s13071-019-3341-y