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Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d1bd566d1ef45ee8751996b23711dac

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

About this item

Full title

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Publisher

England: BioMed Central Ltd

Journal title

Parasites & vectors, 2019-03, Vol.12 (1), p.98-98, Article 98

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

Rhoptry protein 18 (ROP18) is a key virulence factor of Toxoplasma gondii. The host's immune responses mediated by immune-related GTPases (IRGs) could be blocked by ROP18's kinase activity. ROP18 also interacts with various substrates, such as activating transcription factor 6 beta (ATF6β) and affects multiple physiological functions within host ce...

Alternative Titles

Full title

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8d1bd566d1ef45ee8751996b23711dac

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d1bd566d1ef45ee8751996b23711dac

Other Identifiers

ISSN

1756-3305

E-ISSN

1756-3305

DOI

10.1186/s13071-019-3341-y

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