Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates e...
Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Chemically induced proximity (CIP) is a powerful tool to study cellular functions. However with current CIP inducers it is difficult to directly modulate unligandable and endogenous targets, and therapeutic translational potential is also restricted. Herein, we combine CIP and chemical nanobody engineering and create cell-permeable small molecule-n...
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Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets
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TN_cdi_doaj_primary_oai_doaj_org_article_8d648054d0dc4a5083da010f24e1a7e1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d648054d0dc4a5083da010f24e1a7e1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37237-x
