Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discr...
Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology
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Author / Creator
Rothman, Sarah M. , Tanis, Keith Q. , Gandhi, Pallavi , Malkov, Vladislav , Marcus, Jacob , Pearson, Michelle , Stevens, Richard , Gilliland, Jason , Ware, Christopher , Mahadomrongkul, Veeravan , O’Loughlin, Elaine , Zeballos, Gonzalo , Smith, Roger , Howell, Bonnie J. , Klappenbach, Joel , Kennedy, Matthew and Mirescu, Christian
Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
Alzheimer's disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Aβ) known as plaques and intracellular tau tangles. Coincident with the formation of Aβ plaques is recruitment and activation of glial cells to the plaque forming a plaque niche. In additio...
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Full title
Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology
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TN_cdi_doaj_primary_oai_doaj_org_article_8e009419f5ab45f69aae66002d9935b3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8e009419f5ab45f69aae66002d9935b3
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-018-1265-7
