Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery
Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
To optimize gene delivery to myelinating Schwann cells we compared clinically relevant AAV serotypes and injection routes. AAV9 and AAVrh10 vectors expressing either EGFP or the neuropathy-associated gene
GJB1
/Connexin32 (Cx32) under a myelin specific promoter were injected intrathecally or intravenously in wild type and
Gjb1-
null mic...
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Full title
Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery
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TN_cdi_doaj_primary_oai_doaj_org_article_8e16780b5a43469086b07ce6b9a5240d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8e16780b5a43469086b07ce6b9a5240d
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-02694-1
