Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective th...
Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Human triosephosphate isomerase (HsTIM) is a central glycolytic enzyme and is overexpressed in cancer cells with accelerated glycolysis. Triple-negative breast cancer is highly dependent on glycolysis and is typically treated with a combination of surgery, radiation therapy, and chemotherapy. Deamidated HsTIM was recently proposed as a druggable ta...
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Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_8e40f3105af14974bb2c5361fb6ece02
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8e40f3105af14974bb2c5361fb6ece02
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-08051-0
