Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertens...
Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension
About this item
Full title
Author / Creator
Ulrich, Anna , Wu, Yukyee , Draisma, Harmen , Wharton, John , Swietlik, Emilia M. , Cebola, Inês , Vasilaki, Eleni , Balkhiyarova, Zhanna , Jarvelin, Marjo-Riitta , Auvinen, Juha , Herzig, Karl-Heinz , Coghlan, J. Gerry , Lordan, James , Church, Colin , Howard, Luke S. , Pepke-Zaba, Joanna , Toshner, Mark , Wort, Stephen J. , Kiely, David G. , Condliffe, Robin , Lawrie, Allan , Gräf, Stefan , Morrell, Nicholas W. , Wilkins, Martin R. , Prokopenko, Inga and Rhodes, Christopher J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Pulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We addressed this through epigenome-wide association study (EWAS), testing 865,848 CpG sites for association wi...
Alternative Titles
Full title
Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension
Authors, Artists and Contributors
Author / Creator
Wu, Yukyee
Draisma, Harmen
Wharton, John
Swietlik, Emilia M.
Cebola, Inês
Vasilaki, Eleni
Balkhiyarova, Zhanna
Jarvelin, Marjo-Riitta
Auvinen, Juha
Herzig, Karl-Heinz
Coghlan, J. Gerry
Lordan, James
Church, Colin
Howard, Luke S.
Pepke-Zaba, Joanna
Toshner, Mark
Wort, Stephen J.
Kiely, David G.
Condliffe, Robin
Lawrie, Allan
Gräf, Stefan
Morrell, Nicholas W.
Wilkins, Martin R.
Prokopenko, Inga
Rhodes, Christopher J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8e50277bf2c448aa930fb3478374f053
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8e50277bf2c448aa930fb3478374f053
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-44683-0
