A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherap...
A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics
About this item
Full title
Author / Creator
Lee, Hyeong-Min , Wright, William C. , Pan, Min , Low, Jonathan , Currier, Duane , Fang, Jie , Singh, Shivendra , Nance, Stephanie , Delahunty, Ian , Kim, Yuna , Chapple, Richard H. , Zhang, Yinwen , Liu, Xueying , Steele, Jacob A. , Qi, Jun , Pruett-Miller, Shondra M. , Easton, John , Chen, Taosheng , Yang, Jun , Durbin, Adam D. and Geeleher, Paul
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process, we conduct large-scale targeted CRISPR knockout screens in drug-treated cells, creating a genetic map of druggabl...
Alternative Titles
Full title
A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics
Authors, Artists and Contributors
Author / Creator
Wright, William C.
Pan, Min
Low, Jonathan
Currier, Duane
Fang, Jie
Singh, Shivendra
Nance, Stephanie
Delahunty, Ian
Kim, Yuna
Chapple, Richard H.
Zhang, Yinwen
Liu, Xueying
Steele, Jacob A.
Qi, Jun
Pruett-Miller, Shondra M.
Easton, John
Chen, Taosheng
Yang, Jun
Durbin, Adam D.
Geeleher, Paul
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8ea60511d9b646e7b01a18ad97adfba0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8ea60511d9b646e7b01a18ad97adfba0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-43134-0
