Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein patholo...
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
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Author / Creator
Mastenbroek, Sophie E. , Vogel, Jacob W. , Collij, Lyduine E. , Serrano, Geidy E. , Tremblay, Cécilia , Young, Alexandra L. , Arce, Richard A. , Shill, Holly A. , Driver-Dunckley, Erika D. , Mehta, Shyamal H. , Belden, Christine M. , Atri, Alireza , Choudhury, Parichita , Barkhof, Frederik , Adler, Charles H. , Ossenkoppele, Rik , Beach, Thomas G. and Hansson, Oskar
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathol...
Alternative Titles
Full title
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
Authors, Artists and Contributors
Author / Creator
Vogel, Jacob W.
Collij, Lyduine E.
Serrano, Geidy E.
Tremblay, Cécilia
Young, Alexandra L.
Arce, Richard A.
Shill, Holly A.
Driver-Dunckley, Erika D.
Mehta, Shyamal H.
Belden, Christine M.
Atri, Alireza
Choudhury, Parichita
Barkhof, Frederik
Adler, Charles H.
Ossenkoppele, Rik
Beach, Thomas G.
Hansson, Oskar
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8ead8da20952462faeaafda287e2a07f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8ead8da20952462faeaafda287e2a07f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49402-x
