Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein patholo...
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
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Author / Creator
Mastenbroek, Sophie E. , Vogel, Jacob W. , Collij, Lyduine E. , Serrano, Geidy E. , Tremblay, Cécilia , Young, Alexandra L. , Arce, Richard A. , Shill, Holly A. , Driver-Dunckley, Erika D. , Mehta, Shyamal H. , Belden, Christine M. , Atri, Alireza , Choudhury, Parichita , Barkhof, Frederik , Adler, Charles H. , Ossenkoppele, Rik , Beach, Thomas G. , Hansson, Oskar , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , LU profilområde: Proaktivt åldrande , Institutionen för kliniska vetenskaper, Malmö , Clinical Memory Research , Strategic research areas (SRA) , Lunds universitet , Lunds universitets profilområden , Neurodegenerativ forskning , Klinisk minnesforskning , Lund University Profile areas , Profilområden och andra starka forskningsmiljöer , Lund University , LU Profile Area: Proactive Ageing , MultiPark: Multidisciplinary research focused on Parkinson´s disease , Profile areas and other strong research environments , Neurodegenerative research and Department of Clinical Sciences, Malmö
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathol...
Alternative Titles
Full title
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
Authors, Artists and Contributors
Author / Creator
Vogel, Jacob W.
Collij, Lyduine E.
Serrano, Geidy E.
Tremblay, Cécilia
Young, Alexandra L.
Arce, Richard A.
Shill, Holly A.
Driver-Dunckley, Erika D.
Mehta, Shyamal H.
Belden, Christine M.
Atri, Alireza
Choudhury, Parichita
Barkhof, Frederik
Adler, Charles H.
Ossenkoppele, Rik
Beach, Thomas G.
Hansson, Oskar
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
LU profilområde: Proaktivt åldrande
Institutionen för kliniska vetenskaper, Malmö
Clinical Memory Research
Strategic research areas (SRA)
Lunds universitet
Lunds universitets profilområden
Neurodegenerativ forskning
Klinisk minnesforskning
Lund University Profile areas
Profilområden och andra starka forskningsmiljöer
Lund University
LU Profile Area: Proactive Ageing
MultiPark: Multidisciplinary research focused on Parkinson´s disease
Profile areas and other strong research environments
Neurodegenerative research
Department of Clinical Sciences, Malmö
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8ead8da20952462faeaafda287e2a07f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8ead8da20952462faeaafda287e2a07f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49402-x
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