EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
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Author / Creator
Kusakabe, Yuko , Chiba, Tetsuhiro , Oshima, Motohiko , Koide, Shuhei , Rizq, Ola , Aoyama, Kazumasa , Ao, Junjie , Kaneko, Tatsuya , Kanzaki, Hiroaki , Kanayama, Kengo , Maeda, Takahiro , Saito, Tomoko , Nakagawa, Ryo , Kobayashi, Kazufumi , Kiyono, Soichiro , Nakamura, Masato , Ogasawara, Sadahisa , Suzuki, Eiichiro , Nakamoto, Shingo , Yasui, Shin , Mikata, Rintaro , Muroyama, Ryosuke , Kanda, Tatsuo , Maruyama, Hitoshi , Kato, Jun , Mimura, Naoya , Ma, Anqi , Jin, Jian , Zen, Yoh , Otsuka, Masayuki , Kaneda, Atsushi , Iwama, Atsushi and Kato, Naoya
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes. Dysregulation of H3K27 trimethylation (H3K27me3) plays an important role in the development and progression of cancers such as hepatocellular carcinoma (HCC). This study investigated the relationship between the...
Alternative Titles
Full title
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
Authors, Artists and Contributors
Author / Creator
Chiba, Tetsuhiro
Oshima, Motohiko
Koide, Shuhei
Rizq, Ola
Aoyama, Kazumasa
Ao, Junjie
Kaneko, Tatsuya
Kanzaki, Hiroaki
Kanayama, Kengo
Maeda, Takahiro
Saito, Tomoko
Nakagawa, Ryo
Kobayashi, Kazufumi
Kiyono, Soichiro
Nakamura, Masato
Ogasawara, Sadahisa
Suzuki, Eiichiro
Nakamoto, Shingo
Yasui, Shin
Mikata, Rintaro
Muroyama, Ryosuke
Kanda, Tatsuo
Maruyama, Hitoshi
Kato, Jun
Mimura, Naoya
Ma, Anqi
Jin, Jian
Zen, Yoh
Otsuka, Masayuki
Kaneda, Atsushi
Iwama, Atsushi
Kato, Naoya
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8eb58697caf4466e8a01b8253f2d212f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8eb58697caf4466e8a01b8253f2d212f
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-00889-0
