Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1...
Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome
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Author / Creator
Cosentino, Livia , Urbinati, Chiara , Lanzillotta, Chiara , De Rasmo, Domenico , Valenti, Daniela , Pellas, Mattia , Quattrini, Maria Cristina , Piscitelli, Fabiana , Kostrzewa, Magdalena , Di Domenico, Fabio , Pietraforte, Donatella , Bisogno, Tiziana , Signorile, Anna , Vacca, Rosa Anna and De Filippis, Bianca
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett syndrome (RTT), a rare neurologic disorder that severely affects mainly females carrying mutations in the X-linked MECP2 gene. A pool of CB1 cannabinoid receptors (CB1R), the primary receptor sub...
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Full title
Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8f0a63e3f3f04232b7cd24a12f9c6f55
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f0a63e3f3f04232b7cd24a12f9c6f55
Other Identifiers
ISSN
2040-2392
E-ISSN
2040-2392
DOI
10.1186/s13229-024-00617-1
