2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of...
2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity. We examined the effects of 2-oxo-Ado on non-tumour cells, namely immortalized mouse embryonic fibroblast lines, and in...
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2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_8f2b2ee957cb4c88b21e8bfbbc8767d9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f2b2ee957cb4c88b21e8bfbbc8767d9
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2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-06636-8
