MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre-replicative complex (pre-RC) assembly. Currently it is unknown how MCM2-7 ring closure and ATP-hydro...
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Full title
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
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TN_cdi_doaj_primary_oai_doaj_org_article_8f45df5e796d4860b6f65dba8fcaaa88
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f45df5e796d4860b6f65dba8fcaaa88
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-55479-1
